Because of this, a therapy that may work well against a cancer in one stage of its development, may not work at all in an earlier or a later stage. Staying engaged will ensure you get the most from your system as well as keep you up to date on new equipment and features that you can take advantage of. It is well established that hormone therapy alone adds nothing to the survival of localized prostate cancer (see this link and this one). Current methods do not allow us to find most of the cancerous lymph nodes (see this link). We have seen that this is inadequate to reach the cancerous pelvic lymph nodes in over 40% of patients (see this link). As we have seen, prostatectomy, even when followed by radiation (see this link) seems to provide inferior cancer control compared to BBT with WPRT. This may be because the salvage radiation dose to the prostate bed (usually only 66-70 Gy) is inadequate compared to the primary radiation dose (see this link). Although Provenge is more effective when the patient’s disease is less progressed (see this link), it was not any more effective when used for mHSPC in one small study (see this link).

In (and this one), the researchers found that the MRS-detected choline/citrate ratio might be markedly elevated and focal if the cancer is metabolically active, but low and diffuse if there is only benign inflammatory activity. One small observational study suggested that docetaxel may benefit men who are castration-resistant but are not yet detectably metastatic. Many companies are also starting to apply these controls on a mobile app. Quite often the company that does installations for free and may even install the alarm system for free does it because they are looking for the ongoing profit from the alarm monitoring companies services. Because they are already available for another indication, insurance may allow them off-label even sooner. Based on these successes, I’m sure the FDA will fast-track approval for both drugs for this new indication, joining Zytiga and Taxotere. The ideal candidate for Xofigo will get all 6 treatments, preferably earlier, while bone health is still good (see this link). Another fertile area for investigative research is radiosensitization with hyperthermia (see this link). It has been found to work better on smaller tumors, so it is best used earlier rather than later (see this link).

Abiraterone was equally effective regardless of the number of metastases or whether they were classified as higher or lower risk (see this link). Darolutamide and abiraterone (Zytiga) will probably also be approved for this indication. We have learned that the use of abiraterone (Zytiga) in newly-diagnosed metastatic men increases survival markedly over waiting. Experts repeatedly told us that the vast majority of home security system customers use their systems on a sporadic basis. Burglaries are not all that commonplace, so why is it a good idea to have and monitor home security systems? ADT is being ranked fourth all around the world for its best quality security systems. ADT Pulse gives you full control over the ADT home security system. One of the biggest disadvantages of pulse? 4 or more bone mets with at least one beyond the pelvis or vertebrae. In STAMPEDE, early Zytiga increased median survival by at least 18 months; In LATITUDE, early Zytiga increased median survival by16.8 months. Since a full cycle is completed in 24 weeks, taking Xofigo before Zytiga allows one to get the benefit of both in less time. Prostate cancer is one of the most slow-growing of cancers in its early stages.

Pro- and anti-inflammatory cytokines undoubtedly play a role in immune signaling and may occur at different stages. However, there is a kind of MRI called MR Spectroscopy (MRS) that may be able to non-invasively distinguish between bounces and PSA recurrence. There was no difference in 12-year overall survival rates: 60% in the docetaxel group, 55% in the no-docetaxel group. Whether whole pelvic radiation therapy (WPRT) is beneficial for men newly diagnosed with Gleason 9/10 (Grade Group 5) is controversial. We also know that hormone therapy adds nothing to the effectiveness of radiation therapy for favorable risk prostate cancer (see this link and this one and this one). You may see the reputable security companies offering free home security systems, but these usually include a contract and a monthly monitoring fee. Also, contract fees can be tricky. Local options can also provide excellent service. While recurrences usually occur later than bounces, is there a method available for early detection of a local recurrence? Progression is only weakly correlated with time since diagnosis, even for recurrences (see this link). See the updated information below.

Perhaps the fragments generated by chemo or radiation may make the cancer more susceptible to immune attack (see this link). We have already seen that docetaxel is of limited (if any) use when combined with radiation therapy and ADT for high risk cancer patients (see this link). Is whole pelvic radiation needed for primary treatment of Gleason 9/10? So if you contact Groupon about this, they just tell you that you have to turn down the whole thing to get a refund and they won’t pay you back for any extra you had to pay. Non-metastatic castration-resistant prostate cancer is probably an early version of metastatic castration-resistant prostate cancer, where micrometastases have not yet grown large enough to become detectable on a bone scan/CT. ADT vs ADT-alone in non-metastatic men with a recurrence after primary treatment. Erleada (apalutamide) has already been FDA-approved for use in non-metastatic castration-resistant prostate cancer (non-m CRPC), which affects relatively few men (remembering that metastatic was defined by bone scan/CT rather than PET scan).

Ismael White Media